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ROME Therapeutics, Inc.

Biotechnology

ROME Therapeutics Stock

ROME Therapeutics pioneers innovative treatments by exploring the dark genome, or the vast portion of human DNA overlooked by traditional drug discovery. Focusing on genomic repeats that activate in diseased cells, they aim to develop therapies for cancer, autoimmune disorders, and more. Their approach leverages advanced data science and insights into repeat biology to transform these unique genetic elements into groundbreaking treatments.

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ROME Therapeutics Company Overview

ROME Therapeutics was founded with a mission to explore and exploit the dark genome, which comprises 98% of human DNA and has been largely ignored by conventional drug discovery methods. By focusing on genomic repeats—DNA sequences that are typically inactive but can become reactivated in diseased cells—ROME aims to develop novel therapies for a range of serious diseases, including cancer and autoimmune disorders. The company utilizes a sophisticated data science platform to analyze these genomic repeats and understand their roles in disease. One of their primary areas of research is the LINE-1 reverse transcriptase, a protein that can cause inflammation and genomic instability when activated. This protein is linked to several conditions, including cancer, autoimmune diseases, neurodegenerative disorders, and aging. By targeting LINE-1, ROME Therapeutics seeks to develop first-in-class treatments that address the underlying mechanisms of these diseases. ROME Therapeutics' leadership includes experts in genomics, biotechnology, and drug development, who bring a wealth of experience and innovation to the company's research efforts. Their approach integrates advanced data analysis with biological insights, enabling the identification of new therapeutic targets within the dark genome. This pioneering work has the potential to transform the treatment landscape for many complex diseases. In addition to their focus on LINE-1, ROME Therapeutics is developing a robust pipeline of drug candidates aimed at various indications. Their comprehensive approach to exploring the dark genome opens up new possibilities for understanding and treating diseases that have eluded traditional therapies. By harnessing the power of this vast, unexplored genetic territory, ROME Therapeutics is poised to make significant advances in precision medicine, offering hope for more effective and targeted treatments.

Management Team

Rosana Kapeller, MD, PhD Co-founder, President and CEO
Heike Keilhack, PhD Chief Scientific Officer
Kyle Kuvalanka CFO and Chief Business Officer

Funding Information